3zc7: Difference between revisions
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{{STRUCTURE_3zc7| PDB=3zc7 | SCENE= }} | |||
===VbhT Fic protein from Bartonella schoenbuchensis in complex with VbhA antitoxin and ATP=== | |||
{{ABSTRACT_PUBMED_23738009}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/VBHT_BARSR VBHT_BARSR]] Toxic component of a toxin-antitoxin (TA) module VbhT-VbhA. Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific residue of host GTPases. The resulting AMPylation affects GTPases, impairing actin assembly in infected cells. [[http://www.uniprot.org/uniprot/VBHA_BARSR VBHA_BARSR]] Antitoxin component of a toxin-antitoxin (TA) module VbhT-VbhA. Acts by inhibiting the adenylyltransferase activity of VbhT; competes with ATP-binding and prevents productive ATP-binding to VbhT. | |||
==About this Structure== | |||
[[3zc7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bartonella_schoenbuchensis Bartonella schoenbuchensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZC7 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023738009</ref><references group="xtra"/><references/> | |||
[[Category: Bartonella schoenbuchensis]] | |||
[[Category: Goepfert, A.]] | |||
[[Category: Schirmer, T.]] | |||
[[Category: Adenylylation]] | |||
[[Category: Ampylation]] | |||
[[Category: Transferase-antitoxin complex]] | |||
Revision as of 16:11, 19 June 2013
VbhT Fic protein from Bartonella schoenbuchensis in complex with VbhA antitoxin and ATP
Template:ABSTRACT PUBMED 23738009
Function
[VBHT_BARSR] Toxic component of a toxin-antitoxin (TA) module VbhT-VbhA. Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific residue of host GTPases. The resulting AMPylation affects GTPases, impairing actin assembly in infected cells. [VBHA_BARSR] Antitoxin component of a toxin-antitoxin (TA) module VbhT-VbhA. Acts by inhibiting the adenylyltransferase activity of VbhT; competes with ATP-binding and prevents productive ATP-binding to VbhT.
About this Structure
3zc7 is a 2 chain structure with sequence from Bartonella schoenbuchensis. Full crystallographic information is available from OCA.
Reference
- Goepfert A, Stanger FV, Dehio C, Schirmer T. Conserved inhibitory mechanism and competent ATP binding mode for adenylyltransferases with fic fold. PLoS One. 2013 May 30;8(5):e64901. doi: 10.1371/journal.pone.0064901. Print 2013. PMID:23738009 doi:10.1371/journal.pone.0064901
