4b20: Difference between revisions
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{{STRUCTURE_4b20| PDB=4b20 | SCENE= }} | |||
===Structural basis of DNA loop recognition by Endonuclease V=== | |||
{{ABSTRACT_PUBMED_23313664}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NFI_THEMA NFI_THEMA]] Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair. In vitro, can also cleave single-stranded substrates with inosine, double-stranded DNA with apurinic sites, or DNA sites with uracil or a mismatched base. When present in molar excess, two protein molecules can bind to the same DNA substrate and effect cleavage of both strands (in vitro).<ref>PMID:12081482</ref> | |||
==About this Structure== | |||
[[4b20]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B20 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Deoxyribonuclease V]] | |||
[[Category: Thermotoga maritima]] | |||
[[Category: Alseth, I.]] | |||
[[Category: Bjoras, M.]] | |||
[[Category: Dalhus, B.]] | |||
[[Category: Forstrom, R J.]] | |||
[[Category: Rosnes, I.]] | |||
[[Category: Rowe, A D.]] | |||
[[Category: Hydrolase]] | |||
Revision as of 20:22, 17 April 2013
Structural basis of DNA loop recognition by Endonuclease V
Template:ABSTRACT PUBMED 23313664
Function
[NFI_THEMA] Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair. In vitro, can also cleave single-stranded substrates with inosine, double-stranded DNA with apurinic sites, or DNA sites with uracil or a mismatched base. When present in molar excess, two protein molecules can bind to the same DNA substrate and effect cleavage of both strands (in vitro).[1]
About this Structure
4b20 is a 6 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA.
