4h8j: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structure of GluA2-LBD in complex with MES===

The ~~entry 4h8j~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>

~~Authors~~: ~~Reiter, A~~.~~, Skerra, A~~.~~, Trauner, D~~.~~, Schiefner, A~~.

==About this Structure==

[[4h8j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H8J OCA].

~~Description~~: ~~Structure of GluA2~~-~~LBD in complex with MES~~

==Reference==

[[Category: Rattus norvegicus]]

[[Category: Reiter, A.]]

[[Category: Schiefner, A.]]

[[Category: Skerra, A.]]

[[Category: Trauner, D.]]

[[Category: Ampa receptor]]

[[Category: Glycoprotein]]

[[Category: Ion channel]]

[[Category: Ion transport]]

[[Category: Ionotropic glutamate receptor]]

[[Category: Ligand-binding domain]]

[[Category: Membrane protein]]

[[Category: Me]]

[[Category: Postsynaptic cell membrane]]

[[Category: Signaling protein]]

[[Category: Synapse]]

[[Category: Transmembrane protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4h8j|  PDB=4h8j  |  SCENE=  }}
+===Structure of GluA2-LBD in complex with MES===
-The entry 4h8j is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
-Authors: Reiter, A., Skerra, A., Trauner, D., Schiefner, A.
+==About this Structure==
+[[4h8j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H8J OCA].
-Description: Structure of GluA2-LBD in complex with MES
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Rattus norvegicus]]
+[[Category: Reiter, A.]]
+[[Category: Schiefner, A.]]
+[[Category: Skerra, A.]]
+[[Category: Trauner, D.]]
+[[Category: Ampa receptor]]
+[[Category: Glycoprotein]]
+[[Category: Ion channel]]
+[[Category: Ion transport]]
+[[Category: Ionotropic glutamate receptor]]
+[[Category: Ligand-binding domain]]
+[[Category: Membrane protein]]
+[[Category: Me]]
+[[Category: Postsynaptic cell membrane]]
+[[Category: Signaling protein]]
+[[Category: Synapse]]
+[[Category: Transmembrane protein]]