4hu4: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of EAL domain of the E. coli DosP - dimeric form===

~~The entry 4hu4~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/DOSP_ECOLI DOSP_ECOLI]] Heme-based oxygen sensor protein displaying phosphodiesterase (PDE) activity toward c-di-GMP in response to oxygen availability. Involved in the modulation of intracellular c-di-GMP levels, in association with DosC which catalyzes the biosynthesis of c-di-GMP (diguanylate cyclase activity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Has very poor PDE activity on cAMP (PubMed:15995192) but is not active with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate (PubMed:11970957). Via its PDE activity on c-di-GMP, DosP regulates biofilm formation through the repression of transcription of the csgBAC operon, which encodes curli structural subunits.<ref>PMID:20553324</ref>

~~Authors~~: ~~Tarnawski, M~~.~~, Barends, T~~.R.M.~~, Hartmann, E~~.~~, Schlichting, I~~.

==About this Structure==

[[4hu4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HU4 OCA].

~~Description~~:

==Reference==

[[Category: Cyclic-guanylate-specific phosphodiesterase]]

[[Category: Escherichia coli k-12]]

[[Category: Barends, T R.M.]]

[[Category: Hartmann, E.]]

[[Category: Schlichting, I.]]

[[Category: Tarnawski, M.]]

[[Category: Cyclic di-gmp phosphodiesterase]]

[[Category: Direct oxygen sensor]]

[[Category: Eal domain]]

[[Category: Ecdo]]

[[Category: Hydrolase]]

[[Category: Signaling protein]]

[[Category: Tim-barrel]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4hu4|  PDB=4hu4  |  SCENE=  }}
+===Crystal structure of EAL domain of the E. coli DosP - dimeric form===
+{{ABSTRACT_PUBMED_23695249}}
-The entry 4hu4 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/DOSP_ECOLI DOSP_ECOLI]] Heme-based oxygen sensor protein displaying phosphodiesterase (PDE) activity toward c-di-GMP in response to oxygen availability. Involved in the modulation of intracellular c-di-GMP levels, in association with DosC which catalyzes the biosynthesis of c-di-GMP (diguanylate cyclase activity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Has very poor PDE activity on cAMP (PubMed:15995192) but is not active with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate (PubMed:11970957). Via its PDE activity on c-di-GMP, DosP regulates biofilm formation through the repression of transcription of the csgBAC operon, which encodes curli structural subunits.<ref>PMID:20553324</ref>
-Authors: Tarnawski, M., Barends, T.R.M., Hartmann, E., Schlichting, I.
+==About this Structure==
+[[4hu4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HU4 OCA].
-Description:
+==Reference==
+<ref group="xtra">PMID:023695249</ref><references group="xtra"/><references/>
+[[Category: Cyclic-guanylate-specific phosphodiesterase]]
+[[Category: Escherichia coli k-12]]
+[[Category: Barends, T R.M.]]
+[[Category: Hartmann, E.]]
+[[Category: Schlichting, I.]]
+[[Category: Tarnawski, M.]]
+[[Category: Cyclic di-gmp phosphodiesterase]]
+[[Category: Direct oxygen sensor]]
+[[Category: Eal domain]]
+[[Category: Ecdo]]
+[[Category: Hydrolase]]
+[[Category: Signaling protein]]
+[[Category: Tim-barrel]]