1qz6: Difference between revisions
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[[Image:1qz6.jpg|left|200px]] | [[Image:1qz6.jpg|left|200px]] | ||
'''Structure of rabbit actin in complex with jaspisamide A''' | {{Structure | ||
|PDB= 1qz6 |SIZE=350|CAPTION= <scene name='initialview01'>1qz6</scene>, resolution 1.60Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=SUC:SUCROSE'>SUC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ATP:ADENOSINE-5'-TRIPHOSPHATE'>ATP</scene> and <scene name='pdbligand=JAS:JASPISAMIDE A'>JAS</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''Structure of rabbit actin in complex with jaspisamide A''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1QZ6 is a [ | 1QZ6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ6 OCA]. | ||
==Reference== | ==Reference== | ||
Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin., Klenchin VA, Allingham JS, King R, Tanaka J, Marriott G, Rayment I, Nat Struct Biol. 2003 Dec;10(12):1058-63. Epub 2003 Oct 26. PMID:[http:// | Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin., Klenchin VA, Allingham JS, King R, Tanaka J, Marriott G, Rayment I, Nat Struct Biol. 2003 Dec;10(12):1058-63. Epub 2003 Oct 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14578936 14578936] | ||
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: SUC]] | [[Category: SUC]] | ||
[[Category: actin]] | [[Category: actin]] | ||
[[Category: jaspisamide | [[Category: jaspisamide some]] | ||
[[Category: toxin]] | [[Category: toxin]] | ||
[[Category: trisoxazole]] | [[Category: trisoxazole]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:44:48 2008'' | ||
Revision as of 11:44, 20 March 2008
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| 1qz6, resolution 1.60Å | |||||||||||||
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| Ligands: | SUC, CA, ATP and JAS | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Structure of rabbit actin in complex with jaspisamide A
Overview
Marine macrolide toxins of trisoxazole family target actin with high affinity and specificity and have promising pharmacological properties. We present X-ray structures of actin in complex with two members of this family, kabiramide C and jaspisamide A, at a resolution of 1.45 and 1.6 A, respectively. The structures reveal the absolute stereochemistry of these toxins and demonstrate that their trisoxazole ring interacts with actin subdomain 1 while the aliphatic side chain is inserted into the hydrophobic cavity between actin subdomains 1 and 3. The binding site is essentially the same as the one occupied by the actin-capping domain of the gelsolin superfamily of proteins. The structural evidence suggests that actin filament severing and capping by these toxins is also analogous to that of gelsolin. Consequently, these macrolides may be viewed as small molecule biomimetics of an entire class of actin-binding proteins.
About this Structure
1QZ6 is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.
Reference
Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin., Klenchin VA, Allingham JS, King R, Tanaka J, Marriott G, Rayment I, Nat Struct Biol. 2003 Dec;10(12):1058-63. Epub 2003 Oct 26. PMID:14578936
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