1cwo: Difference between revisions

The crystal structure of (Thr2, Leu5, d-Hiv8, Leu10)-cyclosporin (cyclic, peptolide SDZ 214-103) has been determined as the unbound crystal form and, as a complex with human cyclophilin A. This pair of structures provides an, example of a significant difference in conformation between free and bound, ligand in crystals. The conformation of the unbound form is unlike that of, both free and bound conformations of cyclosporin A (with the amide bond, between residues 3 and 4 in the cis conformation), while the bound, conformation is similar to that of CsA bound to cyclophilin. The, cyclophilin-bound conformations of both ligands are similar, though this, involves a significantly different waterellipsisligand hydrogen-bonding, structure, which compensates for the chemical differences between ... [[http://ispc.weizmann.ac.il/pmbin/getpm?9769217 (full description)]]

1CWO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8]]. Structure known Active Site: BIN. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CWO OCA]].  

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