3pg6: Difference between revisions
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[[ | ==The carboxyl terminal domain of human deltex 3-like== | ||
<StructureSection load='3pg6' size='340' side='right' caption='[[3pg6]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3pg6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PG6 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BBAP, DTX3L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pg6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pg6 RCSB], [http://www.ebi.ac.uk/pdbsum/3pg6 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Human Deltex 3-like (DTX3L) is a member of the Deltex family of proteins. Initially identified as a B-lymphoma and BAL-associated protein, DTX3L is an E3 ligase that regulates subcellular localization of its partner protein, BAL, by a dynamic nucleocytoplasmic trafficking mechanism. Unlike other members of the Deltex family of proteins, DTX3L lacks the highly basic N-terminal motif and the central proline-rich motif present in other Deltex proteins, and instead contains other unique N-terminal domains. The C-terminal domains are, however, homologous with other members of the Deltex family of proteins; these include a RING domain and a previously unidentified C-terminal domain. In this study, we report the high-resolution crystal structure of this previously uncharacterized C-terminal domain of human DTX3L, which we term the Deltex C-terminal domain. | |||
Fold of the conserved DTC domain in Deltex proteins.,Obiero J, Walker JR, Dhe-Paganon S Proteins. 2012 May;80(5):1495-9. doi: 10.1002/prot.24054. Epub 2012 Mar 13. PMID:22411408<ref>PMID:22411408</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
==See Also== | |||
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | |||
== | == References == | ||
[[ | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C | [[Category: Bountra, C]] | ||
[[Category: Dhe-Paganon, S | [[Category: Dhe-Paganon, S]] | ||
[[Category: Edwards, A M | [[Category: Edwards, A M]] | ||
[[Category: Kania, J | [[Category: Kania, J]] | ||
[[Category: Obiero, J | [[Category: Obiero, J]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Schuler, H | [[Category: Schuler, H]] | ||
[[Category: Walker, J R | [[Category: Walker, J R]] | ||
[[Category: Weigelt, J | [[Category: Weigelt, J]] | ||
[[Category: Chromatin regulator]] | [[Category: Chromatin regulator]] | ||
[[Category: Dna-damage]] | [[Category: Dna-damage]] | ||
| Line 27: | Line 40: | ||
[[Category: Phosphorylation]] | [[Category: Phosphorylation]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Ubl conjugation pathway]] | [[Category: Ubl conjugation pathway]] | ||
[[Category: Zinc-finger]] | [[Category: Zinc-finger]] | ||
