3uc9: Difference between revisions
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[[ | ==Crystal Structure of Yeast Irc6p - A Novel Type of Conserved Clathrin Accessory Protein== | ||
<StructureSection load='3uc9' size='340' side='right' caption='[[3uc9]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3uc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UC9 FirstGlance]. <br> | |||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IRC6, YFR043C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uc9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uc9 RCSB], [http://www.ebi.ac.uk/pdbsum/3uc9 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Clathrin coat accessory proteins play key roles in transport mediated by clathrin-coated vesicles. Yeast Irc6p and the related mammalian p34 are putative clathrin accessory proteins that interact with clathrin adaptor complexes. Here we present evidence that Irc6p functions in clathrin-mediated traffic between the TGN and endosomes, linking clathrin adaptor complex AP-1 and the Rab GTPase Ypt31p. The crystal structure of the Irc6p N-terminal domain revealed a G protein fold most related to small G proteins of the Rab and Arf families. However, Irc6p lacks G protein signature motifs and high-affinity GTP binding. Also, mutant Irc6p lacking candidate GTP-binding residues retained function. Mammalian p34 rescued growth defects in irc6 cells indicating functional conservation, and modeling predicted a similar N-terminal fold in p34. Irc6p and p34 also contain functionally conserved C-terminal regions. Irc6p/p34-related proteins with the same two-part architecture are encoded in genomes of species as diverse as plants and humans. Together these results define Irc6p/p34 as a novel type of conserved clathrin accessory protein and founding members of a new G protein-like family. | |||
Yeast Irc6p is a novel type of conserved clathrin coat accessory factor related to small G proteins.,Gorynia S, Lorenz TC, Costaguta G, Daboussi L, Cascio D, Payne GS Mol Biol Cell. 2012 Sep 19. PMID:22993212<ref>PMID:22993212</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
== | __TOC__ | ||
</StructureSection> | |||
[[Category: Saccharomyces cerevisiae s288c]] | [[Category: Saccharomyces cerevisiae s288c]] | ||
[[Category: Cascio, D | [[Category: Cascio, D]] | ||
[[Category: Gorynia, S | [[Category: Gorynia, S]] | ||
[[Category: Payne, G S | [[Category: Payne, G S]] | ||
[[Category: Sawaya, M R | [[Category: Sawaya, M R]] | ||
[[Category: Clathrin accessory factor]] | [[Category: Clathrin accessory factor]] | ||
[[Category: Recombination]] | [[Category: Recombination]] | ||
[[Category: Rossmann-fold]] | [[Category: Rossmann-fold]] | ||
Revision as of 15:21, 9 December 2014
Crystal Structure of Yeast Irc6p - A Novel Type of Conserved Clathrin Accessory Protein
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