SandboxPKA: Difference between revisions

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The c-Abl protein 1 (ABL1), also known as Abelson kinase, is a non-receptor tyrosine kinase that plays a role in many key processes linked to cell growth and survival. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. In more than 90% cases, chronic myelogeneous leukemia (CML) is caused by chromosomal abnormality resulting in the formation of a so-called Philadelphia chromosome. ~~This~~ is caused by (9;22) chromosomal-translocation and results in the head-to-tail fusion of the BCR and ABL1, leading a constitutive activation of this tyrosine kinase.

The c-Abl protein 1 (ABL1), also known as Abelson kinase, is a non-receptor tyrosine kinase that plays a role in many key processes linked to cell growth and survival. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. In more than 90% cases, chronic myelogeneous leukemia (CML) is caused by chromosomal abnormality resulting in the formation of a so-called Philadelphia chromosome. It is caused by (9;22) chromosomal-translocation and results in the head-to-tail fusion of the BCR and ABL1, leading a constitutive activation of this tyrosine kinase.

== '''Structure''' ==

SandboxPKA: Difference between revisions

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   <Structure load='1opl' size='400' frame='true' align='right' caption='ABL1 homo-dimer complex' scene='SandboxPKA/Abl1_homo-dimer_complex/1'' />
-The c-Abl protein 1 (ABL1), also known as Abelson kinase, is a non-receptor tyrosine kinase that plays a role in many key processes linked to cell growth and survival. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. In more than 90% cases, chronic myelogeneous leukemia (CML) is caused by chromosomal abnormality resulting in the formation of a so-called Philadelphia chromosome. This is caused by (9;22) chromosomal-translocation and results in the head-to-tail fusion of the BCR and ABL1, leading a constitutive activation of this tyrosine kinase.
+The c-Abl protein 1 (ABL1), also known as Abelson kinase, is a non-receptor tyrosine kinase that plays a role in many key processes linked to cell growth and survival. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. In more than 90% cases, chronic myelogeneous leukemia (CML) is caused by chromosomal abnormality resulting in the formation of a so-called Philadelphia chromosome. It is caused by (9;22) chromosomal-translocation and results in the head-to-tail fusion of the BCR and ABL1, leading a constitutive activation of this tyrosine kinase.
 == '''Structure''' ==