2vx3: Difference between revisions

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~~[[Image:2vx3.png|left|200px]]~~

===Crystal structure of the human dual specificity tyrosine- phosphorylation-regulated kinase 1A===

===~~Crystal structure~~ of the ~~human dual specificity tyrosine- phosphorylation-regulated kinase 1A===~~

==Disease==

[[http://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[http://omim.org/entry/614104 614104]]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref>

~~{{ABSTRACT_PUBMED_021126318}}~~

==Function==

[[http://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>

==About this Structure==

[[2vx3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VX3 OCA].

==Reference==

[[Category: Dual-specificity kinase]]

[[Category: Homo sapiens]]

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-[[Image:2vx3.png|left|200px]]
 {{STRUCTURE_2vx3|  PDB=2vx3  |  SCENE=  }}
+===Crystal structure of the human dual specificity tyrosine- phosphorylation-regulated kinase 1A===
+{{ABSTRACT_PUBMED_021126318}}
-===Crystal structure of the human dual specificity tyrosine- phosphorylation-regulated kinase 1A===
+==Disease==
+[[http://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[http://omim.org/entry/614104 614104]]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref>
-{{ABSTRACT_PUBMED_021126318}}
+==Function==
+[[http://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>
 ==About this Structure==
 [[2vx3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VX3 OCA].
+==Reference==
+<references group="xtra"/><references/>
 [[Category: Dual-specificity kinase]]
 [[Category: Homo sapiens]]