1ro6: Difference between revisions

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[[Image:1ro6.gif|left|200px]]<br /><applet load="1ro6" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ro6.gif|left|200px]]
caption="1ro6, resolution 2.0&Aring;" />
 
'''Crystal structure of PDE4B2B complexed with Rolipram (R & S)'''<br />
{{Structure
|PDB= 1ro6 |SIZE=350|CAPTION= <scene name='initialview01'>1ro6</scene>, resolution 2.0&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ARS:ARSENIC'>ARS</scene> and <scene name='pdbligand=ROL:ROLIPRAM'>ROL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17]
|GENE= PDE4B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of PDE4B2B complexed with Rolipram (R & S)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1RO6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=MN:'>MN</scene>, <scene name='pdbligand=ARS:'>ARS</scene> and <scene name='pdbligand=ROL:'>ROL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RO6 OCA].  
1RO6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RO6 OCA].  


==Reference==
==Reference==
Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram., Xu RX, Rocque WJ, Lambert MH, Vanderwall DE, Luther MA, Nolte RT, J Mol Biol. 2004 Mar 19;337(2):355-65. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15003452 15003452]
Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram., Xu RX, Rocque WJ, Lambert MH, Vanderwall DE, Luther MA, Nolte RT, J Mol Biol. 2004 Mar 19;337(2):355-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15003452 15003452]
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: rolipram]]
[[Category: rolipram]]


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