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[[Image:1n96.png|left|200px]]
==DIMERIC SOLUTION STRUCTURE OF THE CYCLIC OCTAMER CD(CGCTCATT)==
<StructureSection load='1n96' size='340' side='right' caption='[[1n96]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1n96]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N96 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1eu2|1eu2]], [[1eu6|1eu6]]</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n96 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n96 RCSB], [http://www.ebi.ac.uk/pdbsum/1n96 PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The solution structure of a cyclic oligonucleotide d&lt;pCGCTCATT&gt; has been determined by two-dimensional NMR spectroscopy and restrained molecular dynamics. Under the appropriate experimental conditions, this molecule self-associates, forming a symmetric dimer stabilized by four intermolecular Watson-Crick base pairs. The resulting four-stranded structure consists of two G:C:A:T tetrads, formed by facing the minor groove side of the Watson-Crick base-pairs. Most probably, the association of the base-pairs is stabilized by coordinating a Na(+) cation. This is the first time that this novel G:C:A:T tetrad has been found in an oligonucleotide structure. This observation increases considerably the number of sequences that may adopt a four-stranded architecture. Overall, the three-dimensional structure is similar to those observed previously in other quadruplexes formed by minor groove alignment of Watson-Crick base pairs. This resemblance strongly suggests that we may be observing a general motif for DNA-DNA recognition.


{{STRUCTURE_1n96|  PDB=1n96  |  SCENE=  }}
Four-stranded DNA structure stabilized by a novel G:C:A:T tetrad.,Escaja N, Gelpi JL, Orozco M, Rico M, Pedroso E, Gonzalez C J Am Chem Soc. 2003 May 14;125(19):5654-62. PMID:12733903<ref>PMID:12733903</ref>


===DIMERIC SOLUTION STRUCTURE OF THE CYCLIC OCTAMER CD(CGCTCATT)===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_12733903}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[1n96]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N96 OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:012890667</ref><references group="xtra"/>
[[Category: Escaja, N.]]
[[Category: Escaja, N.]]
[[Category: Gelpi, J L.]]
[[Category: Gelpi, J L.]]
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