1n6c: Difference between revisions

Line 1:

~~[[Image:1n6c.png|left|200px]]~~

===Structure of SET7/9===

~~{{ABSTRACT_PUBMED_12514135}}~~

==Function==

[[http://www.uniprot.org/uniprot/SETD7_HUMAN SETD7_HUMAN]] Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.<ref>PMID:12588998</ref> <ref>PMID:15099517</ref> <ref>PMID:16141209</ref> <ref>PMID:17108971</ref> <ref>PMID:12540855</ref> <ref>PMID:15525938</ref>

==About this Structure==

[[1n6c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6C OCA].

[[1n6c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6C OCA].

==See Also==

*[[Histone methyltransferase|Histone methyltransferase]]

==Reference==

[[Category: ~~Homo sapiens~~]]

[[Category: Human]]

[[Category: Chang, J H.]]

[[Category: Cho, Y.]]

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@@ Line 1: / Line 1: @@
-[[Image:1n6c.png|left|200px]]
 {{STRUCTURE_1n6c|  PDB=1n6c  |  SCENE=  }}
 ===Structure of SET7/9===
+{{ABSTRACT_PUBMED_12514135}}
-{{ABSTRACT_PUBMED_12514135}}
+==Function==
+[[http://www.uniprot.org/uniprot/SETD7_HUMAN SETD7_HUMAN]] Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.<ref>PMID:12588998</ref> <ref>PMID:15099517</ref> <ref>PMID:16141209</ref> <ref>PMID:17108971</ref> <ref>PMID:12540855</ref> <ref>PMID:15525938</ref>
 ==About this Structure==
-[[1n6c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6C OCA].
+[[1n6c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6C OCA].
+==See Also==
+*[[Histone methyltransferase|Histone methyltransferase]]
 ==Reference==
-<ref group="xtra">PMID:012514135</ref><references group="xtra"/>
+<ref group="xtra">PMID:012514135</ref><references group="xtra"/><references/>
-[[Category: Homo sapiens]]
+[[Category: Human]]
 [[Category: Chang, J H.]]
 [[Category: Cho, Y.]]