1rrw: Difference between revisions

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[[Image:1rrw.gif|left|200px]]<br /><applet load="1rrw" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1rrw.gif|left|200px]]
caption="1rrw, resolution 2.21&Aring;" />
 
'''DHNA complexed with 9-methylguanine'''<br />
{{Structure
|PDB= 1rrw |SIZE=350|CAPTION= <scene name='initialview01'>1rrw</scene>, resolution 2.21&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=9MG:9-METHYLGUANINE'>9MG</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydroneopterin_aldolase Dihydroneopterin aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.25 4.1.2.25]
|GENE= FOLB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])
}}
 
'''DHNA complexed with 9-methylguanine'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1RRW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] with <scene name='pdbligand=9MG:'>9MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Dihydroneopterin_aldolase Dihydroneopterin aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.25 4.1.2.25] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RRW OCA].  
1RRW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RRW OCA].  


==Reference==
==Reference==
Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization., Sanders WJ, Nienaber VL, Lerner CG, McCall JO, Merrick SM, Swanson SJ, Harlan JE, Stoll VS, Stamper GF, Betz SF, Condroski KR, Meadows RP, Severin JM, Walter KA, Magdalinos P, Jakob CG, Wagner R, Beutel BA, J Med Chem. 2004 Mar 25;47(7):1709-18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15027862 15027862]
Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization., Sanders WJ, Nienaber VL, Lerner CG, McCall JO, Merrick SM, Swanson SJ, Harlan JE, Stoll VS, Stamper GF, Betz SF, Condroski KR, Meadows RP, Severin JM, Walter KA, Magdalinos P, Jakob CG, Wagner R, Beutel BA, J Med Chem. 2004 Mar 25;47(7):1709-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15027862 15027862]
[[Category: Dihydroneopterin aldolase]]
[[Category: Dihydroneopterin aldolase]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: dhna complexed with 9-methylguanine]]
[[Category: dhna complexed with 9-methylguanine]]


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