1rt2: Difference between revisions

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[[Image:1rt2.jpg|left|200px]]<br /><applet load="1rt2" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1rt2.jpg|left|200px]]
caption="1rt2, resolution 2.55&Aring;" />
 
'''CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH TNK-651'''<br />
{{Structure
|PDB= 1rt2 |SIZE=350|CAPTION= <scene name='initialview01'>1rt2</scene>, resolution 2.55&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=TNK:6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL'>TNK</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]
|GENE= HIV-1 POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH TNK-651'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1RT2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=TNK:'>TNK</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RT2 OCA].  
1RT2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RT2 OCA].  


==Reference==
==Reference==
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors., Hopkins AL, Ren J, Esnouf RM, Willcox BE, Jones EY, Ross C, Miyasaka T, Walker RT, Tanaka H, Stammers DK, Stuart DI, J Med Chem. 1996 Apr 12;39(8):1589-600. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8648598 8648598]
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors., Hopkins AL, Ren J, Esnouf RM, Willcox BE, Jones EY, Ross C, Miyasaka T, Walker RT, Tanaka H, Stammers DK, Stuart DI, J Med Chem. 1996 Apr 12;39(8):1589-600. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8648598 8648598]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: nucleotidyltransferase]]
[[Category: nucleotidyltransferase]]


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