1l0a: Difference between revisions
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{{STRUCTURE_1l0a| PDB=1l0a | SCENE= }} | {{STRUCTURE_1l0a| PDB=1l0a | SCENE= }} | ||
===DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3=== | |||
{{ABSTRACT_PUBMED_12005438}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/TRAF3_HUMAN TRAF3_HUMAN]] Defects in TRAF3 are the cause of susceptibility to herpes simplex encephalitis 3 (HSE3) [MIM:[http://omim.org/entry/614849 614849]]. A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.<ref>PMID:20832341</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TRAF3_HUMAN TRAF3_HUMAN]] Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.<ref>PMID:15383523</ref><ref>PMID:15084608</ref><ref>PMID:17991829</ref><ref>PMID:20097753</ref><ref>PMID:20185819</ref><ref>PMID:19937093</ref> [[http://www.uniprot.org/uniprot/TANK_HUMAN TANK_HUMAN]] Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity.<ref>PMID:12133833</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:012005438</ref><references group="xtra"/> | <ref group="xtra">PMID:012005438</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Cabezas, E.]] | [[Category: Cabezas, E.]] | ||
