1rv7: Difference between revisions

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[[Image:1rv7.gif|left|200px]]<br /><applet load="1rv7" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1rv7.gif|left|200px]]
caption="1rv7, resolution 2.70&Aring;" />
 
'''Crystal structures of a Multidrug-Resistant HIV-1 Protease Reveal an Expanded Active Site Cavity'''<br />
{{Structure
|PDB= 1rv7 |SIZE=350|CAPTION= <scene name='initialview01'>1rv7</scene>, resolution 2.70&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=AB1:N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE'>AB1</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE= HIV-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''Crystal structures of a Multidrug-Resistant HIV-1 Protease Reveal an Expanded Active Site Cavity'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1RV7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=AB1:'>AB1</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RV7 OCA].  
1RV7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RV7 OCA].  


==Reference==
==Reference==
Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity., Logsdon BC, Vickrey JF, Martin P, Proteasa G, Koepke JI, Terlecky SR, Wawrzak Z, Winters MA, Merigan TC, Kovari LC, J Virol. 2004 Mar;78(6):3123-32. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14990731 14990731]
Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity., Logsdon BC, Vickrey JF, Martin P, Proteasa G, Koepke JI, Terlecky SR, Wawrzak Z, Winters MA, Merigan TC, Kovari LC, J Virol. 2004 Mar;78(6):3123-32. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14990731 14990731]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Winters, M A.]]
[[Category: Winters, M A.]]
[[Category: AB1]]
[[Category: AB1]]
[[Category: aids]]
[[Category: aid]]
[[Category: aspartyl protease]]
[[Category: aspartyl protease]]
[[Category: hiv protease]]
[[Category: hiv protease]]
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[[Category: polyprotein]]
[[Category: polyprotein]]


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