1kf9: Difference between revisions

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~~[[Image:1kf9.png|left|200px]]~~

===PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR===

==~~=PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR=~~==

==Disease==

[[http://www.uniprot.org/uniprot/GHR_HUMAN GHR_HUMAN]] Defects in GHR are a cause of Laron syndrome (LARS) [MIM:[http://omim.org/entry/262500 262500]]. A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone.<ref>PMID:2779634</ref><ref>PMID:8421103</ref><ref>PMID:8504296</ref><ref>PMID:8450064</ref><ref>PMID:8137822</ref><ref>PMID:9024232</ref><ref>PMID:9661642</ref><ref>PMID:9851797</ref><ref>PMID:10870033</ref><ref>PMID:14678285</ref> Defects in GHR may be a cause of idiopathic short stature autosomal (ISSA) [MIM:[http://omim.org/entry/604271 604271]]. Short stature is defined by a subnormal rate of growth.<ref>PMID:7565946</ref>

~~{{ABSTRACT_PUBMED_11851338}}~~

==Function==

[[http://www.uniprot.org/uniprot/GHR_HUMAN GHR_HUMAN]] Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Kossiakoff, A A.]]

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@@ Line 1: / Line 1: @@
-[[Image:1kf9.png|left|200px]]
 {{STRUCTURE_1kf9|  PDB=1kf9  |  SCENE=  }}
+===PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR===
+{{ABSTRACT_PUBMED_11851338}}
-===PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR===
+==Disease==
+[[http://www.uniprot.org/uniprot/GHR_HUMAN GHR_HUMAN]] Defects in GHR are a cause of Laron syndrome (LARS) [MIM:[http://omim.org/entry/262500 262500]]. A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone.<ref>PMID:2779634</ref><ref>PMID:8421103</ref><ref>PMID:8504296</ref><ref>PMID:8450064</ref><ref>PMID:8137822</ref><ref>PMID:9024232</ref><ref>PMID:9661642</ref><ref>PMID:9851797</ref><ref>PMID:10870033</ref><ref>PMID:14678285</ref>  Defects in GHR may be a cause of idiopathic short stature autosomal (ISSA) [MIM:[http://omim.org/entry/604271 604271]]. Short stature is defined by a subnormal rate of growth.<ref>PMID:7565946</ref>
-{{ABSTRACT_PUBMED_11851338}}
+==Function==
+[[http://www.uniprot.org/uniprot/GHR_HUMAN GHR_HUMAN]] Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity).  The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.  Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.
 ==About this Structure==
@@ Line 11: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:011851338</ref><references group="xtra"/>
+<ref group="xtra">PMID:011851338</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Kossiakoff, A A.]]