1lb6: Difference between revisions

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~~[[Image:1lb6.png|left|200px]]~~

===TRAF6-CD40 Complex===

===~~TRAF6~~-~~CD40 Complex===~~

==Disease==

[[http://www.uniprot.org/uniprot/TNR5_HUMAN TNR5_HUMAN]] Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3) [MIM:[http://omim.org/entry/606843 606843]]. A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.<ref>PMID:11675497</ref>

~~{{ABSTRACT_PUBMED_12140561}}~~

==Function==

[[http://www.uniprot.org/uniprot/TRAF6_HUMAN TRAF6_HUMAN]] E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.<ref>PMID:8837778</ref><ref>PMID:11057907</ref><ref>PMID:16378096</ref><ref>PMID:17135271</ref><ref>PMID:18093978</ref><ref>PMID:18758450</ref><ref>PMID:19675569</ref><ref>PMID:19713527</ref><ref>PMID:12140561</ref><ref>PMID:19465916</ref> [[http://www.uniprot.org/uniprot/TNR5_HUMAN TNR5_HUMAN]] Receptor for TNFSF5/CD40LG.

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Arron, J R.]]

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@@ Line 1: / Line 1: @@
-[[Image:1lb6.png|left|200px]]
 {{STRUCTURE_1lb6|  PDB=1lb6  |  SCENE=  }}
+===TRAF6-CD40 Complex===
+{{ABSTRACT_PUBMED_12140561}}
-===TRAF6-CD40 Complex===
+==Disease==
+[[http://www.uniprot.org/uniprot/TNR5_HUMAN TNR5_HUMAN]] Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3) [MIM:[http://omim.org/entry/606843 606843]]. A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.<ref>PMID:11675497</ref>
-{{ABSTRACT_PUBMED_12140561}}
+==Function==
+[[http://www.uniprot.org/uniprot/TRAF6_HUMAN TRAF6_HUMAN]] E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.<ref>PMID:8837778</ref><ref>PMID:11057907</ref><ref>PMID:16378096</ref><ref>PMID:17135271</ref><ref>PMID:18093978</ref><ref>PMID:18758450</ref><ref>PMID:19675569</ref><ref>PMID:19713527</ref><ref>PMID:12140561</ref><ref>PMID:19465916</ref> [[http://www.uniprot.org/uniprot/TNR5_HUMAN TNR5_HUMAN]] Receptor for TNFSF5/CD40LG.
 ==About this Structure==
@@ Line 11: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:012140561</ref><references group="xtra"/>
+<ref group="xtra">PMID:012140561</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Arron, J R.]]