1ng2: Difference between revisions
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{{STRUCTURE_1ng2| PDB=1ng2 | SCENE= }} | {{STRUCTURE_1ng2| PDB=1ng2 | SCENE= }} | ||
===Structure of autoinhibited p47phox=== | |||
{{ABSTRACT_PUBMED_12732142}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/NCF1_HUMAN NCF1_HUMAN]] Defects in NCF1 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 1 (CGD1) [MIM:[http://omim.org/entry/233700 233700]]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.<ref>PMID:2011585</ref><ref>PMID:11133775</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NCF1_HUMAN NCF1_HUMAN]] NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).<ref>PMID:19801500</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:012732142</ref><references group="xtra"/> | <ref group="xtra">PMID:012732142</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Groemping, Y.]] | [[Category: Groemping, Y.]] | ||
