1s1w: Difference between revisions

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[[Image:1s1w.gif|left|200px]]<br /><applet load="1s1w" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1s1w.gif|left|200px]]
caption="1s1w, resolution 2.70&Aring;" />
 
'''Crystal structure of V106A mutant HIV-1 reverse transcriptase in complex with UC-781'''<br />
{{Structure
|PDB= 1s1w |SIZE=350|CAPTION= <scene name='initialview01'>1s1w</scene>, resolution 2.70&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=UC1:2-METHYL-FURAN-3-CARBOTHIOIC ACID [4-CHLORO-3-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-AMIDE'>UC1</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]
|GENE= POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Human immunodeficiency virus type 1 (isolate HXB2)])
}}
 
'''Crystal structure of V106A mutant HIV-1 reverse transcriptase in complex with UC-781'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1S1W is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_hxb2) Human immunodeficiency virus type 1 (isolate hxb2)] with <scene name='pdbligand=UC1:'>UC1</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1W OCA].  
1S1W is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_hxb2) Human immunodeficiency virus type 1 (isolate hxb2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1W OCA].  


==Reference==
==Reference==
Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors., Ren J, Nichols CE, Chamberlain PP, Weaver KL, Short SA, Stammers DK, J Mol Biol. 2004 Feb 20;336(3):569-78. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15095972 15095972]
Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors., Ren J, Nichols CE, Chamberlain PP, Weaver KL, Short SA, Stammers DK, J Mol Biol. 2004 Feb 20;336(3):569-78. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15095972 15095972]
[[Category: Human immunodeficiency virus type 1 (isolate hxb2)]]
[[Category: Human immunodeficiency virus type 1 (isolate hxb2)]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Stammers, D K.]]
[[Category: Stammers, D K.]]
[[Category: UC1]]
[[Category: UC1]]
[[Category: aids]]
[[Category: aid]]
[[Category: drug resistance mutations]]
[[Category: drug resistance mutation]]
[[Category: hiv-1 reverse transcriptase]]
[[Category: hiv-1 reverse transcriptase]]
[[Category: nnrti]]
[[Category: nnrti]]
[[Category: uc-781]]
[[Category: uc-781]]


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