1mpv: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "1mpv" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_1mpv| PDB=1mpv | SCENE= }} | {{STRUCTURE_1mpv| PDB=1mpv | SCENE= }} | ||
===Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide=== | |||
{{ABSTRACT_PUBMED_12387744}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN]] Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:[http://omim.org/entry/613494 613494]]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:19666484</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN]] B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.<ref>PMID:11591325</ref><ref>PMID:12387744</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[1mpv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPV OCA]. | [[1mpv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPV OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Cochran, A G.]] | [[Category: Cochran, A G.]] | ||
[[Category: Dixit, V M.]] | [[Category: Dixit, V M.]] | ||
