Molecular Playground/Transferrin: Difference between revisions
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Transferrin delivers iron to iron requiring cells by receptor-mediated endocytosis. At basic pH of cell surface diferric human transferrin binds to human transferrin receptor (hTfR). Upon binding, diferric hTf-hTfR is internalized in the cell by endocytosis. In the acidic condition of endosome iron is release from diferric hTf-hTfR complex into the cells. The ApohTf-hTfR complex is recycled back to the cell surface and at the basic pH of cell surface Tf dissociates from the TfR to bind iron again.<ref>PMID: 16271884</ref><ref>PMID: 6300904</ref>. | Transferrin delivers iron to iron requiring cells by receptor-mediated endocytosis. At basic pH of cell surface diferric human transferrin binds to human transferrin receptor (hTfR). Upon binding, diferric hTf-hTfR is internalized in the cell by endocytosis. In the acidic condition of endosome iron is release from diferric hTf-hTfR complex into the cells. The ApohTf-hTfR complex is recycled back to the cell surface and at the basic pH of cell surface Tf dissociates from the TfR to bind iron again.<ref>PMID: 16271884</ref><ref>PMID: 6300904</ref>. | ||
At low pH iron is released from N-lobe by protonation of <scene name='Molecular_Playground/Transferrin/N_lobe_fe_release/2'>Lysines</scene> 206 and 296 <ref>PMID: 9609685</ref> and from C-lobe | |||
<scene name='Molecular_Playground/Transferrin/N_lobe_fe_release/2'>Lysines</scene>206 and 296 | |||
