Heidi Hu/Sandbox 2: Difference between revisions

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== Introduction ==

Heavy metals such as iron, nickel, copper, and zinc are important cofactors for the functions of many different metalloenzymes. High levels of these heavy metals can also cause damage to cellular components, therefore intracellular levels of metals are tightly regulated within the cell. One of the ways that bacteria can regulate intracellular metal levels is by increasing the amount of metal efflux proteins. CsoR and RcnR are members of a large family of metal-responsive DNA-binding proteins, both of which regulate the transcription of metal-specific efflux proteins. CsoR is only responsive to the binding of Cu(I); whereas RcnR is only responsive to the binding of Ni(II) or Co(II).~~<ref>PMID:21511390</ref>~~

[http://en.wikipedia.org/wiki/Helicobacter_pylori ''Helicobacter pylori''] is a pathogenic bacterium that colonizes the human gastric mucosa, which can cause peptic ulcers and has been linked to stomach cancers. Nickel is an important nutrient for [http://en.wikipedia.org/wiki/Helicobacter_pylori ''H. pylori''].<ref>PMID:9146793</ref>

Heavy metals such as iron, nickel, copper, and zinc are important cofactors for the functions of many different metalloenzymes. High levels of these heavy metals can also cause damage to cellular components, therefore intracellular levels of metals are tightly regulated within the cell. One of the ways that bacteria can regulate intracellular metal levels is by increasing the amount of metal efflux proteins. CsoR and RcnR are members of a large family of metal-responsive DNA-binding proteins, both of which regulate the transcription of metal-specific efflux proteins. CsoR is only responsive to the binding of Cu(I); whereas RcnR is only responsive to the binding of Ni(II) or Co(II).

Heidi Hu/Sandbox 2: Difference between revisions

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 == Introduction ==
-Heavy metals such as iron, nickel, copper, and zinc are important cofactors for the functions of many different metalloenzymes.  High levels of these heavy metals can also cause damage to cellular components, therefore intracellular levels of metals are tightly regulated within the cell.  One of the ways that bacteria can regulate intracellular metal levels is by increasing the amount of metal efflux proteins.  CsoR and RcnR are members of a large family of metal-responsive DNA-binding proteins, both of which regulate the transcription of metal-specific efflux proteins.  CsoR is only responsive to the binding of Cu(I); whereas RcnR is only responsive to the binding of Ni(II) or Co(II).<ref>PMID:21511390</ref>
+[http://en.wikipedia.org/wiki/Helicobacter_pylori ''Helicobacter pylori''] is a pathogenic bacterium that colonizes the human gastric mucosa, which can cause peptic ulcers and has been linked to stomach cancers.  Nickel is an important nutrient for [http://en.wikipedia.org/wiki/Helicobacter_pylori ''H. pylori''].<ref>PMID:9146793</ref>
+Heavy metals such as iron, nickel, copper, and zinc are important cofactors for the functions of many different metalloenzymes.  High levels of these heavy metals can also cause damage to cellular components, therefore intracellular levels of metals are tightly regulated within the cell.  One of the ways that bacteria can regulate intracellular metal levels is by increasing the amount of metal efflux proteins.  CsoR and RcnR are members of a large family of metal-responsive DNA-binding proteins, both of which regulate the transcription of metal-specific efflux proteins.  CsoR is only responsive to the binding of Cu(I); whereas RcnR is only responsive to the binding of Ni(II) or Co(II).