SandboxPKA: Difference between revisions

• '''Gly-rich loop (GxGxxG):'''  this loop folds over the nucleotide and positions the γ-phosphate of ATP for catalysis and is the most flexible part of the N-lobe.  

• '''<scene name='Dasatinib/Mpl/4'>P-Loop Movement</scene>'''<  often referred to as the Walker-A motif (GxxxxGKT/S) <Ref>PMID: 12468712</Ref>. In this loop there is a higly conserved residue (usually Lys) which is able to form a salt bridge with the C-helix.  

• '''C-helix''':  is a unique helix present in the N-lobe. It is very dynamic and plays a key role as a regulatory element in the protein kinase molecule. C-helix occupies a strategically important position between the two lobes. The C-helix connects many different parts of the molecule and serves as a ‘‘signal integration motif’’ <Ref>PMID: 11749372</Ref> The C-helix contains another conserved residue, Glu or Asp, that bridges to a Lys residue located in the P-loop. This bridge is essential for the catalytic process.