2m13: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===The ZZ domain of cytoplasmic polyadenylation element binding protein 1 (CPEB1)===

~~The entry 2m13~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/CPEB1_HUMAN CPEB1_HUMAN]] Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.<ref>PMID:15966895</ref> <ref>PMID:15731006</ref>

~~Authors~~: ~~Lee, B~~.M.~~, Merkel, D~~.J.~~, Wells, S~~.B.~~, Hilburn, B.C., Elazzouzi, F., Perez~~-~~Alvarado, G.C~~.

==About this Structure==

[[2m13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M13 OCA].

~~Description~~: ~~The ZZ domain of cytoplasmic polyadenylation element~~ binding protein ~~1 (CPEB1)~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Elazzouzi, F.]]

[[Category: Hilburn, B C.]]

[[Category: Lee, B M.]]

[[Category: Merkel, D J.]]

[[Category: Perez-Alvarado, G C.]]

[[Category: Wells, S B.]]

[[Category: Metal binding protein]]

[[Category: Zinc-binding protein]]

[[Category: Zz motif]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_2m13|  PDB=2m13  |  SCENE=  }}
+===The ZZ domain of cytoplasmic polyadenylation element binding protein 1 (CPEB1)===
+{{ABSTRACT_PUBMED_23500490}}
-The entry 2m13 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/CPEB1_HUMAN CPEB1_HUMAN]] Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.<ref>PMID:15966895</ref> <ref>PMID:15731006</ref>
-Authors: Lee, B.M., Merkel, D.J., Wells, S.B., Hilburn, B.C., Elazzouzi, F., Perez-Alvarado, G.C.
+==About this Structure==
+[[2m13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M13 OCA].
-Description: The ZZ domain of cytoplasmic polyadenylation element binding protein 1 (CPEB1)
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Elazzouzi, F.]]
+[[Category: Hilburn, B C.]]
+[[Category: Lee, B M.]]
+[[Category: Merkel, D J.]]
+[[Category: Perez-Alvarado, G C.]]
+[[Category: Wells, S B.]]
+[[Category: Metal binding protein]]
+[[Category: Zinc-binding protein]]
+[[Category: Zz motif]]