1s8n: Difference between revisions
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'''Crystal structure of Rv1626 from Mycobacterium tuberculosis''' | {{Structure | ||
|PDB= 1s8n |SIZE=350|CAPTION= <scene name='initialview01'>1s8n</scene>, resolution 1.482Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=AZI:AZIDE ION'>AZI</scene> | |||
|ACTIVITY= | |||
|GENE= rv1626 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 Mycobacterium tuberculosis H37Rv]) | |||
}} | |||
'''Crystal structure of Rv1626 from Mycobacterium tuberculosis''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1S8N is a [ | 1S8N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S8N OCA]. | ||
==Reference== | ==Reference== | ||
The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis., Morth JP, Feng V, Perry LJ, Svergun DI, Tucker PA, Structure. 2004 Sep;12(9):1595-605. PMID:[http:// | The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis., Morth JP, Feng V, Perry LJ, Svergun DI, Tucker PA, Structure. 2004 Sep;12(9):1595-605. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15341725 15341725] | ||
[[Category: Mycobacterium tuberculosis h37rv]] | [[Category: Mycobacterium tuberculosis h37rv]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: psi]] | [[Category: psi]] | ||
[[Category: rv1626]] | [[Category: rv1626]] | ||
[[Category: structural | [[Category: structural genomic]] | ||
[[Category: tb structural genomics consortium]] | [[Category: tb structural genomics consortium]] | ||
[[Category: tbsgc]] | [[Category: tbsgc]] | ||
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[[Category: two component system]] | [[Category: two component system]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:01:53 2008'' | ||
Revision as of 12:01, 20 March 2008
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| 1s8n, resolution 1.482Å | |||||||||||||
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| Ligands: | AZI | ||||||||||||
| Gene: | rv1626 (Mycobacterium tuberculosis H37Rv) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of Rv1626 from Mycobacterium tuberculosis
Overview
We describe the crystal structure of Rv1626 from Mycobacterium tuberculosis at 1.48 A resolution and the corresponding solution structure determined from small angle X-ray scattering. The N-terminal domain shows structural homology to the receiver domains found in bacterial two-component systems. The C-terminal domain has high structural homology to a recently discovered RNA binding domain involved in transcriptional antitermination. The molecule in solution was found to be monomeric as it is in the crystal, but in solution it undergoes a conformational change that is triggered by changes in ionic strength. This is the first structure that links the phosphorylation cascade of the two-component systems with the antitermination event in the transcriptional machinery. Rv1626 belongs to a family of proteins, which we propose calling phosphorylation-dependent transcriptional antitermination regulators, so far only found in bacteria, and includes NasT, a protein from the assimilatory nitrate/nitrite reductase operon of Azetobacter vinelandii.
About this Structure
1S8N is a Single protein structure of sequence from Mycobacterium tuberculosis h37rv. Full crystallographic information is available from OCA.
Reference
The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis., Morth JP, Feng V, Perry LJ, Svergun DI, Tucker PA, Structure. 2004 Sep;12(9):1595-605. PMID:15341725
Page seeded by OCA on Thu Mar 20 14:01:53 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Mycobacterium tuberculosis h37rv
- Single protein
- Feng, V.
- Morth, J P.
- Perry, L J.
- Svergun, D I.
- TBSGC, TB Structural Genomics Consortium.
- Tucker, P A.
- AZI
- Protein structure initiative
- Psi
- Rv1626
- Structural genomic
- Tb structural genomics consortium
- Tbsgc
- Transcriptional antiterminator
- Two component system
