1sc8: Difference between revisions

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[[Image:1sc8.gif|left|200px]]<br /><applet load="1sc8" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1sc8.gif|left|200px]]
caption="1sc8, resolution 2.4&Aring;" />
 
'''Urokinase Plasminogen Activator B-Chain-J435 Complex'''<br />
{{Structure
|PDB= 1sc8 |SIZE=350|CAPTION= <scene name='initialview01'>1sc8</scene>, resolution 2.4&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=2IN:N-(BENZYLSULFONYL)SERYL-N~1~-{4-[AMINO(IMINO)METHYL]BENZYL}GLYCINAMIDE'>2IN</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73]
|GENE= homo ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Urokinase Plasminogen Activator B-Chain-J435 Complex'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1SC8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=2IN:'>2IN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SC8 OCA].  
1SC8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SC8 OCA].  


==Reference==
==Reference==
Design of novel and selective inhibitors of urokinase-type plasminogen activator with improved pharmacokinetic properties for use as antimetastatic agents., Schweinitz A, Steinmetzer T, Banke IJ, Arlt MJ, Sturzebecher A, Schuster O, Geissler A, Giersiefen H, Zeslawska E, Jacob U, Kruger A, Sturzebecher J, J Biol Chem. 2004 Aug 6;279(32):33613-22. Epub 2004 May 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15150279 15150279]
Design of novel and selective inhibitors of urokinase-type plasminogen activator with improved pharmacokinetic properties for use as antimetastatic agents., Schweinitz A, Steinmetzer T, Banke IJ, Arlt MJ, Sturzebecher A, Schuster O, Geissler A, Giersiefen H, Zeslawska E, Jacob U, Kruger A, Sturzebecher J, J Biol Chem. 2004 Aug 6;279(32):33613-22. Epub 2004 May 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15150279 15150279]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: urokinase]]
[[Category: urokinase]]


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