1sdu: Difference between revisions

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[[Image:1sdu.jpg|left|200px]]<br /><applet load="1sdu" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1sdu.jpg|left|200px]]
caption="1sdu, resolution 1.25&Aring;" />
 
'''Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site.'''<br />
{{Structure
|PDB= 1sdu |SIZE=350|CAPTION= <scene name='initialview01'>1sdu</scene>, resolution 1.25&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene> and <scene name='pdbligand=MK1:N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE'>MK1</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE= gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site.'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1SDU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=ACT:'>ACT</scene> and <scene name='pdbligand=MK1:'>MK1</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SDU OCA].  
1SDU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SDU OCA].  


==Reference==
==Reference==
Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site., Mahalingam B, Wang YF, Boross PI, Tozser J, Louis JM, Harrison RW, Weber IT, Eur J Biochem. 2004 Apr;271(8):1516-24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15066177 15066177]
Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site., Mahalingam B, Wang YF, Boross PI, Tozser J, Louis JM, Harrison RW, Weber IT, Eur J Biochem. 2004 Apr;271(8):1516-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15066177 15066177]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: drug resistance hiv-1 protease]]
[[Category: drug resistance hiv-1 protease]]


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