1osx: Difference between revisions
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{{STRUCTURE_1osx| PDB=1osx | SCENE= }} | {{STRUCTURE_1osx| PDB=1osx | SCENE= }} | ||
===Solution Structure of the Extracellular Domain of BLyS Receptor 3 (BR3)=== | |||
{{ABSTRACT_PUBMED_12755599}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN]] Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:[http://omim.org/entry/613494 613494]]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:19666484</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN]] B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.<ref>PMID:11591325</ref><ref>PMID:12387744</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:012755599</ref><references group="xtra"/> | <ref group="xtra">PMID:012755599</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Cochran, A G.]] | [[Category: Cochran, A G.]] | ||
