1sk6: Difference between revisions

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[[Image:1sk6.gif|left|200px]]<br /><applet load="1sk6" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1sk6.gif|left|200px]]
caption="1sk6, resolution 3.2&Aring;" />
 
'''Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin, 3',5' cyclic AMP (cAMP), and pyrophosphate'''<br />
{{Structure
|PDB= 1sk6 |SIZE=350|CAPTION= <scene name='initialview01'>1sk6</scene>, resolution 3.2&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=CMP:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE'>CMP</scene> and <scene name='pdbligand=POP:PYROPHOSPHATE 2-'>POP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1]
|GENE= CYA, PXO1-122 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])
}}
 
'''Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin, 3',5' cyclic AMP (cAMP), and pyrophosphate'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1SK6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=YB:'>YB</scene>, <scene name='pdbligand=CMP:'>CMP</scene> and <scene name='pdbligand=POP:'>POP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SK6 OCA].  
1SK6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SK6 OCA].  


==Reference==
==Reference==
Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate., Guo Q, Shen Y, Zhukovskaya NL, Florian J, Tang WJ, J Biol Chem. 2004 Jul 9;279(28):29427-35. Epub 2004 May 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15131111 15131111]
Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate., Guo Q, Shen Y, Zhukovskaya NL, Florian J, Tang WJ, J Biol Chem. 2004 Jul 9;279(28):29427-35. Epub 2004 May 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15131111 15131111]
[[Category: Adenylate cyclase]]
[[Category: Adenylate cyclase]]
[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
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[[Category: ef3 camp ppi cam]]
[[Category: ef3 camp ppi cam]]


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