4ht3: Difference between revisions
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{{STRUCTURE_4ht3| PDB=4ht3 | SCENE= }} | |||
===The crystal structure of Salmonella typhimurium Tryptophan Synthase at 1.30A complexed with N-(4'-TRIFLUOROMETHOXYBENZENESULFONYL)-2-AMINO-1-ETHYLPHOSPHATE (F9) inhibitor in the alpha site, internal aldimine=== | |||
{{ABSTRACT_PUBMED_23952479}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/TRPA_SALTY TRPA_SALTY]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [[http://www.uniprot.org/uniprot/TRPB_SALTY TRPB_SALTY]] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. | |||
==About this Structure== | |||
[[4ht3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HT3 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023952479</ref><references group="xtra"/><references/> | |||
[[Category: Tryptophan synthase]] | |||
[[Category: Dunn, M F.]] | |||
[[Category: Fan, L.]] | |||
[[Category: Hilario, E.]] | |||
[[Category: Mueller, L J.]] | |||
[[Category: Niks, D.]] | |||
[[Category: Allosteric enzyme]] | |||
[[Category: Amino-acid biosynthesis]] | |||
[[Category: Aromatic amino acid biosynthesis]] | |||
[[Category: Carbon-oxygen lyase]] | |||
[[Category: Cesium ion]] | |||
[[Category: F9f]] | |||
[[Category: Lyase]] | |||
[[Category: Lyase-lyase inhibitor complex]] | |||
[[Category: Pyridoxal phosphate]] | |||
[[Category: Salmonella]] | |||
[[Category: Tryptophan biosynthesis]] | |||
Revision as of 12:09, 1 January 2014
The crystal structure of Salmonella typhimurium Tryptophan Synthase at 1.30A complexed with N-(4'-TRIFLUOROMETHOXYBENZENESULFONYL)-2-AMINO-1-ETHYLPHOSPHATE (F9) inhibitor in the alpha site, internal aldimine
Template:ABSTRACT PUBMED 23952479
Function
[TRPA_SALTY] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [TRPB_SALTY] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
About this Structure
4ht3 is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Niks D, Hilario E, Dierkers A, Ngo H, Borchardt D, Neubauer TJ, Fan L, Mueller LJ, Dunn MF. Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states. Biochemistry. 2013 Sep 17;52(37):6396-411. doi: 10.1021/bi400795e. Epub 2013 Sep , 6. PMID:23952479 doi:https://dx.doi.org/10.1021/bi400795e
