4hx5: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4hx5|  PDB=4hx5  |  SCENE=  }}
===Crystal structure of 11 beta-HSD1 in complex with SAR184841===
{{ABSTRACT_PUBMED_23478147}}


The entry 4hx5 is ON HOLD  until Nov 09 2014
==Disease==
[[http://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN]] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:[http://omim.org/entry/604931 604931]]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).


Authors: Loenze, P., Schimanski-Breves, S., Engel, C.K.
==Function==
[[http://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).  


Description: Crystal structure of 11 beta-HSD1 in complex with SAR184841
==About this Structure==
[[4hx5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HX5 OCA].
[[Category: 11-beta-hydroxysteroid dehydrogenase]]
[[Category: Homo sapiens]]
[[Category: Engel, C K.]]
[[Category: Loenze, P.]]
[[Category: Schimanski-Breves, S.]]
[[Category: 11beta]]
[[Category: Dehydrogenase]]
[[Category: Hydroxysteroid]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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