1sp4: Difference between revisions

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[[Image:1sp4.jpg|left|200px]]<br /><applet load="1sp4" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1sp4.jpg|left|200px]]
caption="1sp4, resolution 2.20&Aring;" />
 
'''Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed epoxysuccinyl inhibitor extends along the whole active site cleft'''<br />
{{Structure
|PDB= 1sp4 |SIZE=350|CAPTION= <scene name='initialview01'>1sp4</scene>, resolution 2.20&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=EPO:1-OXO-(2-HYDROXYBUTYL)-4-OXO+GROUP'>EPO</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene> and <scene name='pdbligand=PRO:PROLINE'>PRO</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1]
|GENE=
}}
 
'''Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed epoxysuccinyl inhibitor extends along the whole active site cleft'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1SP4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=EPO:'>EPO</scene>, <scene name='pdbligand=LEU:'>LEU</scene> and <scene name='pdbligand=PRO:'>PRO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SP4 OCA].  
1SP4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SP4 OCA].  


==Reference==
==Reference==
Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft., Stern I, Schaschke N, Moroder L, Turk D, Biochem J. 2004 Jul 15;381(Pt 2):511-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15084146 15084146]
Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft., Stern I, Schaschke N, Moroder L, Turk D, Biochem J. 2004 Jul 15;381(Pt 2):511-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15084146 15084146]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Cathepsin B]]
[[Category: Cathepsin B]]
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[[Category: PRO]]
[[Category: PRO]]
[[Category: cathepsin b]]
[[Category: cathepsin b]]
[[Category: epoxysuccinyl-based inhibitors]]
[[Category: epoxysuccinyl-based inhibitor]]
[[Category: inhibitor design]]
[[Category: inhibitor design]]


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