1p9l: Difference between revisions
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{{STRUCTURE_1p9l| PDB=1p9l | SCENE= }} | {{STRUCTURE_1p9l| PDB=1p9l | SCENE= }} | ||
===Structure of M. tuberculosis dihydrodipicolinate reductase in complex with NADH and 2,6 PDC=== | ===Structure of M. tuberculosis dihydrodipicolinate reductase in complex with NADH and 2,6 PDC=== | ||
{{ABSTRACT_PUBMED_12962488}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DAPB_MYCTU DAPB_MYCTU]] Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Can use both NADH and NADPH as a reductant, with NADH being 6-fold as effective as NADPH.<ref>PMID:12962488</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:012962488</ref><references group="xtra"/> | <ref group="xtra">PMID:012962488</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: 4-hydroxy-tetrahydrodipicolinate reductase]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Blanchard, J S.]] | [[Category: Blanchard, J S.]] | ||
Revision as of 05:32, 6 November 2013
Structure of M. tuberculosis dihydrodipicolinate reductase in complex with NADH and 2,6 PDC
Template:ABSTRACT PUBMED 12962488
Function
[DAPB_MYCTU] Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Can use both NADH and NADPH as a reductant, with NADH being 6-fold as effective as NADPH.[1]
About this Structure
1p9l is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
- Cirilli M, Zheng R, Scapin G, Blanchard JS. The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity. Biochemistry. 2003 Sep 16;42(36):10644-50. PMID:12962488 doi:https://dx.doi.org/10.1021/bi030044v
- ↑ Cirilli M, Zheng R, Scapin G, Blanchard JS. The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity. Biochemistry. 2003 Sep 16;42(36):10644-50. PMID:12962488 doi:https://dx.doi.org/10.1021/bi030044v
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- 4-hydroxy-tetrahydrodipicolinate reductase
- Mycobacterium tuberculosis
- Blanchard, J S.
- Cirilli, M.
- Scapin, G.
- TBSGC, TB Structural Genomics Consortium.
- Zheng, R.
- Lysine biosynthesis
- Nadh binding specificity
- Oxidoreductase
- Protein structure initiative
- Psi
- Reductase
- Structural genomic
- Tb structural genomics consortium
- Tbsgc
