1sui: Difference between revisions
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'''Alfalfa caffeoyl coenzyme A 3-O-methyltransferase''' | {{Structure | ||
|PDB= 1sui |SIZE=350|CAPTION= <scene name='initialview01'>1sui</scene>, resolution 2.70Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene> and <scene name='pdbligand=FRE:FERULOYL COENZYME A'>FRE</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Caffeoyl-CoA_O-methyltransferase Caffeoyl-CoA O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.104 2.1.1.104] | |||
|GENE= CCOMT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3879 Medicago sativa]) | |||
}} | |||
'''Alfalfa caffeoyl coenzyme A 3-O-methyltransferase''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1SUI is a [ | 1SUI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Medicago_sativa Medicago sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUI OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structures of alfalfa caffeoyl coenzyme A 3-O-methyltransferase., Ferrer JL, Zubieta C, Dixon RA, Noel JP, Plant Physiol. 2005 Mar;137(3):1009-17. Epub 2005 Feb 25. PMID:[http:// | Crystal structures of alfalfa caffeoyl coenzyme A 3-O-methyltransferase., Ferrer JL, Zubieta C, Dixon RA, Noel JP, Plant Physiol. 2005 Mar;137(3):1009-17. Epub 2005 Feb 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15734921 15734921] | ||
[[Category: Caffeoyl-CoA O-methyltransferase]] | [[Category: Caffeoyl-CoA O-methyltransferase]] | ||
[[Category: Medicago sativa]] | [[Category: Medicago sativa]] | ||
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[[Category: rossmann fold]] | [[Category: rossmann fold]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:09:46 2008'' | ||
Revision as of 12:09, 20 March 2008
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| 1sui, resolution 2.70Å | |||||||||||||
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| Ligands: | CA, SAH and FRE | ||||||||||||
| Gene: | CCOMT (Medicago sativa) | ||||||||||||
| Activity: | Caffeoyl-CoA O-methyltransferase, with EC number 2.1.1.104 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Alfalfa caffeoyl coenzyme A 3-O-methyltransferase
Overview
Caffeoyl coenzyme A 3-O-methyltransferases (CCoAOMTs) are S-adenosyl-l-methionine-dependent O-methyltransferases (OMTs) involved in lignin biosynthesis. Plant CCoAOMTs belong to a distinct family of OMTs, more closely related to the mammalian catechol OMTs than to other plant OMTs. The crystal structure of alfalfa (Medicago sativa) CCoAOMT in complex with the reaction products S-adenosine-l-homocysteine and feruloyl/sinapoyl CoAs presented here belong to a structurally and mechanistically distinct family of plant small molecule OMTs. These structures provide a new understanding of the substrate preferences and the catalytic mechanism accompanying CCoAOMT-mediated O-methylation of CoA-linked phenylpropanoid substrates.
About this Structure
1SUI is a Single protein structure of sequence from Medicago sativa. Full crystallographic information is available from OCA.
Reference
Crystal structures of alfalfa caffeoyl coenzyme A 3-O-methyltransferase., Ferrer JL, Zubieta C, Dixon RA, Noel JP, Plant Physiol. 2005 Mar;137(3):1009-17. Epub 2005 Feb 25. PMID:15734921
Page seeded by OCA on Thu Mar 20 14:09:46 2008
