Sandbox Reserved 705: Difference between revisions
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<!-- PLEASE DO NOT DELETE THIS TEMPLATE --> | <!-- PLEASE DO NOT DELETE THIS TEMPLATE --> | ||
<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | <!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
''' Human Merlin FERM Domain''' | ''' Human Merlin FERM Domain''' | ||
==Introduction == | ==Introduction == | ||
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{{STRUCTURE_3u8z| PDB=3u8z | SCENE=| size='500'}} | {{STRUCTURE_3u8z| PDB=3u8z | SCENE=| size='500'}} | ||
The structure 3U8Z has in total 4 chains. These are represented by 1 sequence-unique entity.The chains A,B and C possess 9 helices and 15 strands and the chain D has only 9 helices and 14 strands. | The structure 3U8Z has in total 4 chains. These are represented by 1 sequence-unique entity.The chains A,B and C possess 9 | ||
<scene name='Sandbox_Reserved_705/Global/2'>helices</scene> and 15 <scene name='Sandbox_Reserved_705/Global/3'>strands</scene> and the chain D has only 9 helices and 14 strands. | |||
===Structural differences=== | ===Structural differences=== | ||
The overall architecture of merlin is similar to that of ERM proteins. Indeed they have almost the same organization : a FERM domain,a central α-helical rod, but lack a C-terminal actin-binding site<ref name= "utile2" />. | The overall architecture of merlin is similar to that of ERM proteins. Indeed they have almost the same organization : a FERM domain,a central α-helical rod, but lack a C-terminal actin-binding site<ref name= "utile2" />. | ||
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CD44 is a cell-surface receptor for hyaluronan (HA a ligand). When HA binds to CD44 the complex promotes tumorigenesis it means it promotes tumor invasion and metastasis. Indeed, CD44 is a receptor presents in the TA3 carcinome mammaire cells and Tr6BC1 schwannoma cells and HA allows their growth. | CD44 is a cell-surface receptor for hyaluronan (HA a ligand). When HA binds to CD44 the complex promotes tumorigenesis it means it promotes tumor invasion and metastasis. Indeed, CD44 is a receptor presents in the TA3 carcinome mammaire cells and Tr6BC1 schwannoma cells and HA allows their growth. | ||
<scene name='Sandbox_Reserved_705/Global/4'>charged</scene> | <scene name='Sandbox_Reserved_705/Global/4'>charged</scene> | ||
