Sandbox Reserved 705: Difference between revisions
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Merlin shares certain properties with the ERM family : they both have a subcellular localization to cortical actin structures and they both bind to adhesion receptors.These receptors are CD44 <ref>PMID:9330869</ref> and E-cadherin <ref>PMID:12695331</ref>. | Merlin shares certain properties with the ERM family : they both have a subcellular localization to cortical actin structures and they both bind to adhesion receptors.These receptors are CD44 <ref>PMID:9330869</ref> and E-cadherin <ref>PMID:12695331</ref>. | ||
However Merlin-1 has some properties not shared with ERM proteins. | However Merlin-1 has some properties not shared with ERM proteins. | ||
'''Further, the binding of a basic cleft that lies between the F1 and F3 subdomains to phosphatidylinositol 4,5-bisphosphate (PIP2) directs ERM proteins to the plasma membrane, and may also sever their head–tail interactions. ''' | |||
==Specificity of merlin FERM domain== | ==Specificity of merlin FERM domain== | ||
