Sandbox Reserved 705: Difference between revisions
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[[Image:inactivestate.gif |thumb|left|650px|Inactive ERM protein]] | [[Image:inactivestate.gif |thumb|left|650px|Inactive ERM protein]] | ||
[[Image:activestate.gif |thumb|right|650px|Active ERM protein]] | [[Image:activestate.gif |thumb|right|650px|Active ERM protein]] | ||
===Regulators of the activity=== | ===Regulators of the activity=== | ||
Phosphorylation of a C-terminal threonine by Rho kinase and binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and protein partners, is necessary for full activation of ERM proteins <ref>PMID:14993232</ref>. They disrupt the head to tail interactions. The phosphorylations and/binding(s) determine the cellular localization and the cellular function of each specific ERM protein. | Phosphorylation of a C-terminal threonine by Rho kinase and binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and protein partners, is necessary for full activation of ERM proteins <ref>PMID:14993232</ref>. They disrupt the head to tail interactions. The phosphorylations and/binding(s) determine the cellular localization and the cellular function of each specific ERM protein. | ||
