Sandbox Reserved 705: Difference between revisions
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Phosphorylation at Ser518 of merlin inactivates its growth inhibitive activity. As we explained this phosphorylation can be achieved by cyclic AMP-dependent protein kinase A (PKA) and p21-activated kinases 1 (PAK1). | Phosphorylation at Ser518 of merlin inactivates its growth inhibitive activity. As we explained this phosphorylation can be achieved by cyclic AMP-dependent protein kinase A (PKA) and p21-activated kinases 1 (PAK1). | ||
Phosphorylation of merlin at Thr230 and Ser315 target the protein for ubiquitination,degradation <ref>PMID:17891137</ref>.This is a mechanism that lowers merlin expression in breast cancer<ref>PMID:21965655</ref>. | Phosphorylation of merlin at Thr230 and Ser315 target the protein for ubiquitination,degradation <ref>PMID:17891137</ref>.This is a mechanism that lowers merlin expression in breast cancer<ref>PMID:21965655</ref>. | ||
However there exist many protein that regulates merlin expression. They may be a | However there exist many protein that regulates merlin expression. They may be a useful therapetic target.Therefore scientist need to further inverstigate to determine the pathways that involve the merlin protein. | ||
