Sandbox Reserved 712: Difference between revisions
From Proteopedia
Jump to navigationJump to search
| Line 8: | Line 8: | ||
3ggu is a drug resistant HIV protease. Shown is a patient's variant in complex with darunavir. | 3ggu is a drug resistant HIV protease. Shown is a patient's variant in complex with darunavir. | ||
HIV proteases(PR) are essential for the functioning of the retrovirus that causes AIDS. HIV needs active proteases to process Gag & Gap - Polymerase polyprotein precursors into mature structural proteins and replicative enzymes. | HIV proteases (PR) are essential for the functioning of the retrovirus that causes AIDS. HIV needs active proteases to process Gag & Gap - Polymerase polyprotein precursors into mature structural proteins and replicative enzymes. | ||
HIV proteases contain a highly conserved region Asp - Thr - Gly (Asp25, Thr26 and Gly27), with the aspartic residue beeing the active site in the aspartyl protease.[[(1)]] | HIV proteases contain a highly conserved region Asp - Thr - Gly (Asp25, Thr26 and Gly27), with the aspartic residue beeing the active site in the aspartyl protease.[[(1)]] | ||
Because of its importance for the life-cycle of the retrovirus, HIV-PR are the major target for | |||
HIV protease inhibitors are the most potent agens used in anti-HIV treatment. However it occurs that HIV PR develops a resistance to the inhibitor. [[(2)]] | Because of its importance for the life-cycle of the retrovirus, HIV-PR are the major target for anti-HIV treatment. | ||
HIV protease inhibitors are the most potent agens used in anti-HIV treatment. However it occurs that HIV-PR develops a resistance to the inhibitor. [[(2)]] | |||
== '''Activity''' == | == '''Activity''' == | ||
