Sandbox Reserved 712: Difference between revisions
From Proteopedia
Jump to navigationJump to search
| Line 47: | Line 47: | ||
== '''Structure''' == | == '''Structure''' == | ||
=== General structure of HIV-1 proteases === | === General structure of HIV-1 proteases === | ||
HIV-1 proteases are essential for HIV to survive. They are small enzymes, which are made out of two identical, 99 amino acids long, protein chains. | |||
These chains form a tunnel, which is covered by so called (flexible) "flaps". The flaps's function is to "wrap around" the substrate-protein and holding it close to the tunnel and therefore to the active site. | |||
In the tunnel the acitve site is located. The acitve site uses water molecules to break the subrate-protein chain. It's most important residues are two aspartate amino acids. | |||
(Inhibitors occupie similar positions like the natural substrate-protein chain.) | |||
<ref>HIV-1 Protease, June 2000 Molecule of the Month by David Goodsell [http://dx.doi.org/10.2210/rcsb_pdb/mom_2000_6 DOI: 10.2210/rcsb_pdb/mom_2000_6]</ref> | |||
=== X-ray structure analysis of 3ggu === | === X-ray structure analysis of 3ggu === | ||
