Sandbox Reserved 717: Difference between revisions
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The receptor-binding domain can be sub-divided into head and bonnet. On the border between these two subdomains there is a metal-binding site. This site binds presumably to zinc. <scene name='Sandbox_Reserved_717/Mynewscene/3'>Two His amino acids </scene> (<scene name='Sandbox_Reserved_717/Mynewscene/1'>His445</scene> and <scene name='Sandbox_Reserved_717/Mynewscene/2'>His447</scene>) from each monomere are octahedrally coordinated around the zinc. | The receptor-binding domain can be sub-divided into head and bonnet. On the border between these two subdomains there is a metal-binding site. This site binds presumably to zinc. <scene name='Sandbox_Reserved_717/Mynewscene/3'>Two His amino acids </scene> (<scene name='Sandbox_Reserved_717/Mynewscene/1'>His445</scene> and <scene name='Sandbox_Reserved_717/Mynewscene/2'>His447</scene>) from each monomere are octahedrally coordinated around the zinc. | ||
The receptor-binding domain can be compared to a flower bud. This flower bud has got 12 petals which are organised in a 3-fold symmetry. At the bottom there are the | The receptor-binding domain can be compared to a flower bud. This flower bud has got 12 petals which are organised in a 3-fold symmetry. At the bottom there are the residues 406-432 they form the <scene name='Sandbox_Reserved_717/Mynewscene/4'>first petal </scene> , just above there are the residues 489-504 which form the <scene name='Sandbox_Reserved_717/Mynewscene/5'>second petal</scene> . The <scene name='Sandbox_Reserved_717/Mynewscene/6'>third petal </scene> is formed by the residues 450-470 and at the top there are the residues 470-480 and form the <scene name='Sandbox_Reserved_717/Mynewscene/7'>fourth petal</scene> . The complete and active receptor-binding domain is built by the trimeric protein. This trimeric proteine structure is stabilised by many inter-domain hydrogen bounds. These hydrogen bounds can have the profiles: main-chain-main-chain, main-chain-side-chain and side-chain-side-chain. | ||
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Aromatic putative binding residues: | Aromatic putative binding residues: | ||
<scene name='Sandbox_Reserved_717/Myscene/8'>Tyr454</scene> ,<scene name='Sandbox_Reserved_717/Myscene/9'>Phe451</scene>, <scene name='Sandbox_Reserved_717/Myscene/10'>Trp477</scene> , Phe468, Phe460, Phe420, Tyr488, Tyr444, His408, Tyr433 | <scene name='Sandbox_Reserved_717/Myscene/8'>Tyr454</scene> ,<scene name='Sandbox_Reserved_717/Myscene/9'>Phe451</scene>, <scene name='Sandbox_Reserved_717/Myscene/10'>Trp477</scene> ,<scene name='Sandbox_Reserved_717/Mynewscene/8'>Phe468</scene> ,<scene name='Sandbox_Reserved_717/Mynewscene/9'>Phe460</scene> ,<scene name='Sandbox_Reserved_717/Mynewscene/10'>Phe420</scene> , Tyr488, Tyr444, His408, Tyr433 | ||
'''It can not be ruled out that also other amino acids are important for binding! Further it can not be ruled out that not all of these named amino acids are important for binding''' | '''It can not be ruled out that also other amino acids are important for binding! Further it can not be ruled out that not all of these named amino acids are important for binding''' | ||
