Tryptophan synthase: Difference between revisions
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Michal Harel (talk | contribs) New page: '''Tryptophan synthase''' (TrpS) is an α2β2 tetramer participating in the biosynthesis of tryptophan. TrpS α subunit catalyzes the formation of indole and glyceraldehyde-3-phospha... |
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{{STRUCTURE_1wbj| PDB=1wbj | SIZE=400| SCENE=|right|CAPTION=Tryptophan synthase α subunit (grey) and β subunit (green) of the α2β2 tetramer complex with pyridoxal-phosphate and glycerol-3-phosphate [[1wbj]]}} | |||
'''Tryptophan synthase''' (TrpS) is an α2β2 tetramer participating in the biosynthesis of tryptophan. TrpS α subunit catalyzes the formation of indole and glyceraldehyde-3-phosphate (G3P) from indole-3-glycerol phosphate (IGP). The β subunit catalyzes in a pyridoxal-phosphate (PLP) dependent reaction the formation of tryptophan (Trp) from indole and serine. The diffusion of indole from the α to the β subunit is facilitated via a hydrophobic channel connecting the subunits. TrpS is not found in animals hence it is tested as a possible drug target for tubertculosis, ocular and genital infections, cryptosporidiosis and as herbicide. | '''Tryptophan synthase''' (TrpS) is an α2β2 tetramer participating in the biosynthesis of tryptophan. TrpS α subunit catalyzes the formation of indole and glyceraldehyde-3-phosphate (G3P) from indole-3-glycerol phosphate (IGP). The β subunit catalyzes in a pyridoxal-phosphate (PLP) dependent reaction the formation of tryptophan (Trp) from indole and serine. The diffusion of indole from the α to the β subunit is facilitated via a hydrophobic channel connecting the subunits. TrpS is not found in animals hence it is tested as a possible drug target for tubertculosis, ocular and genital infections, cryptosporidiosis and as herbicide. | ||
