Sandbox Reserved 718: Difference between revisions
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Lin28 is a conserved cytoplasmic protein with an unusual pairing of RNA binding motifs: a cold shock domain and a pair of retroviral type CCHC zinc fingers. It plays a critical role in developmental transition, glucose metabolism, and tumorigenesis. At the molecular level, LIN28 is known to repress maturation of let-7 microRNAs and enhance translation of certain mRNAs. Mammals have two homologs, Lin28a and Lin28b. These two homologs are found from worms to humans (Cho et al., 2012; Balzer and Moss, 2007). Lin28a is highly expressed in embryonic stem cells (ESCs) and was shown as one of the four factors that convert fibroblasts into induced pluripotent stem cells (Yu et al., 2007). | Lin28 is a conserved cytoplasmic protein with an unusual pairing of RNA binding motifs: a cold shock domain and a pair of retroviral type CCHC zinc fingers. It plays a critical role in developmental transition, glucose metabolism, and tumorigenesis. At the molecular level, LIN28 is known to repress maturation of let-7 microRNAs and enhance translation of certain mRNAs. Mammals have two homologs, Lin28a and Lin28b. These two homologs are found from worms to humans (Cho et al., 2012; Balzer and Moss, 2007). Lin28a is highly expressed in embryonic stem cells (ESCs) and was shown as one of the four factors that convert fibroblasts into induced pluripotent stem cells (Yu et al., 2007). | ||
At the molecular level, LIN28 acts as a suppressor of let-7 microRNA biogenesis (Heo et al., 2008; Newman et al., 2008; Rybak et al., 2008; Viswanathan et al., 2008). In the nucleus, LIN28 binds to the primary transcript of let-7 (pri-let-7) and prevents its processing by RNase III DROSHA (Newman et al., 2008; Viswanathan et al., 2008). In the cytoplasm, it interacts with the precursor form of let-7 (pre-let-7) and interferes with pre-let-7 processing (Heo et al., 2008; Rybak et al., 2008). | |||
Let-7 is a key target of Lin28 but there are multiple additional functions: | Let-7 is a key target of Lin28 but there are multiple additional functions: | ||
