Sandbox Reserved 718: Difference between revisions
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Lin28 is a conserved cytoplasmic protein with an unusual pairing of RNA‑binding motifs: a cold shock domain and a pair of retroviral‑type CCHC zinc fingers. | Lin28 is a conserved cytoplasmic protein with an unusual pairing of RNA‑binding motifs: a cold shock domain and a pair of retroviral‑type CCHC zinc fingers. | ||
Lin28 is a conserved cytoplasmic protein with an unusual pairing of RNA binding motifs: a cold shock domain and a pair of retroviral type CCHC zinc fingers. It plays a critical role in developmental transition, glucose metabolism, and tumorigenesis. At the molecular level, Lin28 is known to repress maturation of let-7 microRNAs and enhance translation of certain mRNAs. Mammals have two homologs, Lin28a and Lin28b. These two homologs are found from worms to humans | Lin28 is a conserved cytoplasmic protein with an unusual pairing of RNA binding motifs: a cold shock domain and a pair of retroviral type CCHC zinc fingers. It plays a critical role in developmental transition, glucose metabolism, and tumorigenesis. At the molecular level, Lin28 is known to repress maturation of let-7 microRNAs and enhance translation of certain mRNAs. Mammals have two homologs, Lin28a and Lin28b. These two homologs are found from worms to humans.<ref>Jun Cho, Hyeshik Chang, S. Chul Kwon, Baekgyu Kim, Yoosik Kim, Junho Choe, Minju Ha, Yoon Ki Kim, and V. Narry Kim: ''Lin28A Is a Suppressor of ER-Associated Translation in Embryonic Stem Cells.'' In: Cell 151, S. 765–777, November 9, 2012</ref><ref>Erica Balzer and Eric G. Moss: ''Localization of the Developmental Timing Regulator Lin28 to mRNP | ||
Complexes, P-bodies and Stress Granules.'' In: RNA Biology 4:1, S. 16-25, January/February/March 2007</ref><ref>http://www.ncbi.nlm.nih.gov/pubmed?term=Localization%20of%20the%20Developmental%20Timing%20Regulator%20Lin28%20to%20mRNP%20Complexes%2C%20P-bodies%20and%20Stress%20Granules</ref>Lin28a is highly expressed in embryonic stem cells (ESCs) and was shown as one of the four factors that convert fibroblasts into induced pluripotent stem cells (Yu et al., 2007). | |||
At the molecular level, Lin28 acts as a suppressor of let-7 microRNA biogenesis (Heo et al., 2008; Newman et al., 2008; Rybak et al., 2008; Viswanathan et al., 2008). In the nucleus, Lin28 binds to the primary transcript of let-7 (pri-let-7) and prevents its processing by RNase III DROSHA (Newman et al., 2008; Viswanathan et al., 2008). In the cytoplasm, it interacts with the precursor form of let-7 (pre-let-7) and interferes with pre-let-7 processing (Heo et al., 2008; Rybak et al., 2008). Lin28 recruits TUTase 4 (ZCCHC11) to induce oligo-uridylation | At the molecular level, Lin28 acts as a suppressor of let-7 microRNA biogenesis (Heo et al., 2008; Newman et al., 2008; Rybak et al., 2008; Viswanathan et al., 2008). In the nucleus, Lin28 binds to the primary transcript of let-7 (pri-let-7) and prevents its processing by RNase III DROSHA (Newman et al., 2008; Viswanathan et al., 2008). In the cytoplasm, it interacts with the precursor form of let-7 (pre-let-7) and interferes with pre-let-7 processing (Heo et al., 2008; Rybak et al., 2008). Lin28 recruits TUTase 4 (ZCCHC11) to induce oligo-uridylation | ||
