3tc3: Difference between revisions
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[[ | ==Crystal Structure of SacUVDE== | ||
<StructureSection load='3tc3' size='340' side='right' caption='[[3tc3]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3tc3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius_dsm_639 Sulfolobus acidocaldarius dsm 639]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TC3 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">uvdE, Saci_1096 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=330779 Sulfolobus acidocaldarius DSM 639])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tc3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tc3 RCSB], [http://www.ebi.ac.uk/pdbsum/3tc3 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Repairing damaged DNA is essential for an organism's survival. UV damage endonuclease (UVDE) is a DNA-repair enzyme that can recognize and incise different types of damaged DNA. We present the structure of Sulfolobus acidocaldarius UVDE on its own and in a pre-catalytic complex with UV-damaged DNA containing a 6-4 photoproduct showing a novel 'dual dinucleotide flip' mechanism for recognition of damaged dipyrimidines: the two purines opposite to the damaged pyrimidine bases are flipped into a dipurine-specific pocket, while the damaged bases are also flipped into another cleft. | |||
UV damage endonuclease employs a novel dual-dinucleotide flipping mechanism to recognize different DNA lesions.,Meulenbroek EM, Peron Cane C, Jala I, Iwai S, Moolenaar GF, Goosen N, Pannu NS Nucleic Acids Res. 2012 Dec 11. PMID:23221644<ref>PMID:23221644</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
== | __TOC__ | ||
</StructureSection> | |||
[[Category: Sulfolobus acidocaldarius dsm 639]] | [[Category: Sulfolobus acidocaldarius dsm 639]] | ||
[[Category: Goosen, N | [[Category: Goosen, N]] | ||
[[Category: Jala, I | [[Category: Jala, I]] | ||
[[Category: Meulenbroek, E M | [[Category: Meulenbroek, E M]] | ||
[[Category: Moolenaar, G F | [[Category: Moolenaar, G F]] | ||
[[Category: Pannu, N S | [[Category: Pannu, N S]] | ||
[[Category: Endonuclease]] | [[Category: Endonuclease]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Tim-barrel]] | [[Category: Tim-barrel]] | ||
