3leo: Difference between revisions
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{{STRUCTURE_3leo| PDB=3leo | SCENE= }} | {{STRUCTURE_3leo| PDB=3leo | SCENE= }} | ||
===Structure of human Leukotriene C4 synthase mutant R31Q in complex with glutathione=== | |||
{{ABSTRACT_PUBMED_20980252}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[http://omim.org/entry/246530 246530]]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020980252</ref><references group="xtra"/> | <ref group="xtra">PMID:020980252</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Haeggstrom, J.]] | [[Category: Haeggstrom, J.]] | ||
Revision as of 22:04, 24 March 2013
Structure of human Leukotriene C4 synthase mutant R31Q in complex with glutathione
Template:ABSTRACT PUBMED 20980252
Disease
[LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
Function
[LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
About this Structure
3leo is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Rinaldo-Matthis A, Wetterholm A, Martinez Molina D, Holm J, Niegowski D, Ohlson E, Nordlund P, Morgenstern R, Haeggstrom JZ. Arginine 104 is a key catalytic residue in leukotriene C4 synthase. J Biol Chem. 2010 Dec 24;285(52):40771-6. Epub 2010 Oct 27. PMID:20980252 doi:10.1074/jbc.M110.105940
