3j2t: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===An improved model of the human apoptosome===

The ~~entry 3j2t is ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/APAF_HUMAN APAF_HUMAN]] Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.<ref>PMID:10393175</ref> <ref>PMID:12804598</ref> [[http://www.uniprot.org/uniprot/CYC_BOVIN CYC_BOVIN]] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).

~~Authors~~: ~~Yuan, S~~.~~, Topf, M~~.~~, Akey, C~~.W.

==About this Structure==

[[3j2t]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3iyt 3iyt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J2T OCA].

~~Description~~: ~~An improved model of the human apoptosome~~

==Reference==

[[Category: Bos taurus]]

[[Category: Homo sapiens]]

[[Category: Akey, C W.]]

[[Category: Topf, M.]]

[[Category: Yuan, S.]]

[[Category: Apaf-1]]

[[Category: Apoptosis]]

[[Category: Apoptosis protease activating factor-1]]

[[Category: Cytochrome c]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_3j2t|  PDB=3j2t  |  SCENE=  }}
+===An improved model of the human apoptosome===
+{{ABSTRACT_PUBMED_23521171}}
-The entry 3j2t is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/APAF_HUMAN APAF_HUMAN]] Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.<ref>PMID:10393175</ref> <ref>PMID:12804598</ref>  [[http://www.uniprot.org/uniprot/CYC_BOVIN CYC_BOVIN]] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.  Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).
-Authors: Yuan, S., Topf, M., Akey, C.W.
+==About this Structure==
+[[3j2t]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entries  and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3iyt 3iyt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J2T OCA].
-Description: An improved model of the human apoptosome
+==Reference==
+<ref group="xtra">PMID:020462491</ref><references group="xtra"/><references/>
+[[Category: Bos taurus]]
+[[Category: Homo sapiens]]
+[[Category: Akey, C W.]]
+[[Category: Topf, M.]]
+[[Category: Yuan, S.]]
+[[Category: Apaf-1]]
+[[Category: Apoptosis]]
+[[Category: Apoptosis protease activating factor-1]]
+[[Category: Cytochrome c]]