3zg2: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Sterol 14 alpha-demethylase (CYP51) from Trypanosoma cruzi in complex with the pyridine inhibitor (S)-2-(4-chlorophenyl)-2-(pyridin-3-yl)-1- (4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethanone (EPL-BS1246,UDO)===

~~The entry 3zg2~~ is ~~ON HOLD until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/CP51_TRYCC CP51_TRYCC]] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.<ref>PMID:16321980</ref> [UniProtKB:P0A512]

~~Authors~~: ~~Hargrove, T~~.Y.~~, Wawrzak, Z~~.~~, Keenan, M~~.~~, Chatelain, E~~.~~, Lepesheva, G~~.I.

==About this Structure==

[[3zg2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZG2 OCA].

~~Description~~: Sterol 14 ~~alpha~~-demethylase ~~(CYP51) from~~ Trypanosoma cruzi ~~in complex with the pyridine inhibitor (S)-2-(4-chlorophenyl)-2-(pyridin-3-yl)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethanone (EPL-BS1246~~,~~UDO)~~

==Reference==

[[Category: Sterol 14-demethylase]]

[[Category: Trypanosoma cruzi]]

[[Category: Chatelain, E.]]

[[Category: Hargrove, T Y.]]

[[Category: Keenan, M.]]

[[Category: Lepesheva, G I.]]

[[Category: Wawrzak, Z.]]

[[Category: Cytochrome p450 fold]]

[[Category: Endoplasmic reticulum membrane]]

[[Category: Eukaryotic membrane]]

[[Category: Inhibitor]]

[[Category: Monooxygenase]]

[[Category: Oxidoreductase]]

[[Category: Sterol biosynthesis]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_3zg2|  PDB=3zg2  |  SCENE=  }}
+===Sterol 14 alpha-demethylase (CYP51) from Trypanosoma cruzi in complex with the pyridine inhibitor (S)-2-(4-chlorophenyl)-2-(pyridin-3-yl)-1- (4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethanone (EPL-BS1246,UDO)===
-The entry 3zg2 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/CP51_TRYCC CP51_TRYCC]] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.<ref>PMID:16321980</ref> [UniProtKB:P0A512]
-Authors: Hargrove, T.Y., Wawrzak, Z., Keenan, M., Chatelain, E., Lepesheva, G.I.
+==About this Structure==
+[[3zg2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZG2 OCA].
-Description: Sterol 14 alpha-demethylase (CYP51) from Trypanosoma cruzi in complex with the pyridine inhibitor (S)-2-(4-chlorophenyl)-2-(pyridin-3-yl)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethanone (EPL-BS1246,UDO)
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Sterol 14-demethylase]]
+[[Category: Trypanosoma cruzi]]
+[[Category: Chatelain, E.]]
+[[Category: Hargrove, T Y.]]
+[[Category: Keenan, M.]]
+[[Category: Lepesheva, G I.]]
+[[Category: Wawrzak, Z.]]
+[[Category: Cytochrome p450 fold]]
+[[Category: Endoplasmic reticulum membrane]]
+[[Category: Eukaryotic membrane]]
+[[Category: Inhibitor]]
+[[Category: Monooxygenase]]
+[[Category: Oxidoreductase]]
+[[Category: Sterol biosynthesis]]